The Application of Reaction NMR: for Real Time Monitoring of Chemical Reactions and Processes. Thomas M. Zennie, Christopher Doecke and Andreas Kaerner, Experimental NMR Conference, Daytona Beach, Florida, April 23, 2007
Application of At-Column-Dilution Sample Delivery System to Improve the Efficiency of LC-NMR Spectroscopic Analyses, Dallas W. Hallberg, John F. Kozlowski, and Thomas M. Zennie, Experimental NMR Conference, Providence, Rhode Island, April 10, 2005
"Development of a scalable process for CI-1034, an endothelin antagonist. Jacks TE., Krikke JJ., McCabe RJ., Mustakis JG., Nanninga TN., Seamans RE. Skeean R., Winkle DD., Zennie TM, Organic Process Research & Development. 8(2):201-212, Mar-Apr, 2004.
An Asymmetric Hydrogenation Based Approach to Atorvastatin Lactone Randall L. DeJong, Victor Fedij, Mark J. Hoekman, Gregory L. Karrick, James J. Krikke, Sechoing Lin, Kenneth E. Mennen, Jason G. Mustakis, Jade D. Nelson*, Michael G. Pamment, Howie I. Tjiong, Aimee M. Weber, Thomas M. Zennie, Chemistry Matters, Pfizer internal quarterly journal, spring 2003.
A Continuous Procedure For the Preparation Of para Functionalized Aromatic Thiols Using Newman-Kwart Chemistry, Sechoing Lin, Thomas M. Zennie and James Wemple, Organic Preparations and Procedures International, 32 (6), 547-555 (2000).
In Pursuit of Higher Purity: Use of 13C NMR and 13C enriched Substrates to Trace Impurity Generation and Removal in the Synthesis of Atorvastatin, Organic Process Research and Development. R.A. Wade, T.M. Zennie, C.A. Briggs, R.A. Jennings and T.N. Nanninga, Vol 4, pp320-324, 6/1997.
"Funebradiol, A New Pyrrole Lactone Alkaloid From Quararibea funebris," T. M. Zennie and J. M. Cassady, Journal Natural Products, 53, 1611-1614, 1990.
"Use of a Mammalian Cell Culture Benzo[a]pyrene Metabolism Assay for the Detection of Potential Anticarcinogens from Natural Products: Inhibition of Metabolism by Biochanin A, an Isofavone from Trifolium pratense L.," J. M. Cassady, T. M. Zennie, Y. H. Chae, M. A. Ferin, N. E. Portuondo, and W. M. Baird, Cancer Research, 48, 6257-6261, 1988.
"Glucolimnanthin, a Plant Glucosinolate, Increases the Metabolism and DNA Binding of Benzo[a]pyrene in Hamster Embryo Cell Cultures," W. M. Baird, T. M. Zennie, M. Ferin, Y. H. Chae, J. Hatchell, and J. M. Cassady, Carcinogensis, Vol. 9, 4, 657-660, 1988.
"Novel 6,7-Seco-6,11-cycloabdane Diterpenes From Cluytia richardiana," J. S. Mossa, J. M. Cassady, J. F. Koslowski, T. M. Zennie, M. D. Antoun, M. G. Pellechia, A. T. McKenzie, and R. S. Byrn, Tetrahedron Letters, 29, 30, 3627-3630, 1988.
"Red Clover (Trifolium pratense) Extracts Inhibit the Metabolism of Benzo(a)pyrene (B(a)P) and B(a)P-DNA Binding in Hamster Embryo Cell Cultures," T. M. Zennie, Y. H. Chae, M. A. Ferin, N. E. Protuando, W. M. Baird, and J. M. Cassady, Cancer Research, 28, 144, March 1987.
"Analysis of Natural Products by Tandem Mass Spectrometry Employing Reactive Collisions with Ethyl Vinyl Ether," R. R. Pachuta, H. I. Kenttumaa, R. G. Cooks, T. M. Zennie, and J. M. Cassady, Organic Mass Spectrometry, 23, 10-15, 1988.
" Edible and Poisonous Plants of Indiana."; T.M. Zennie, Purdue Agr Exp Sta Bull , #530(*):278-285,1987
"The Plant Glucosinolate Glucolimnanthin Increases the Metabolism of Benzo(a)pyrene in Hamster Embryo Cells," T. M. Zennie, W. M. Baird, J. M. Cassady, Cancer Research, 27, 31, March 1986.
"Funebral - A New Pyrrole Lactone Alkaloid From Quararibea funebris Flowers," T. M. Zennie, J. M. Cassady, R. F. Raffauf, Journal of Natural Products, 49, 4, 695-698, 1986.
"Funebrine, A Structurally Novel Pyrrole Alkaloid, and Other Gamma-hydroxy- isoleucine Related Metabolites of Quararibea funebris Llave Vischer (Bombacaceae)," R. R. Raffauf, T. M. Zennie, K. D. Onan, P. W. LeQuesne, Journal of Organic Chemistry, 49, 2714-2718, 1984.
"Fluorescence Enhancement of Aflatoxins: Effects of Free Fatty Acids in Corn Extracts Using Instrumental HPTLC," T. M. Zennie, Journal of Liquid Chromatography, 7, (7), 1383-1391, 1984.
"Identification of Aflatoxin B1 in Grain Elevator Dusts in Central Illinois," T. M. Zennie, Journal of Toxicology and Environmental Health, 13, 589-593, 1984.
"Ethnobotany and Phytochemistry of Quararibea funebris, R. F. Raffauf and T. M. Zennie, Botanical Museum Leaflets, 29, 2, 151-158, 1983.
"The Flavonoid Chemistry of Pistia Stratiotes L. and Origin of the Lemnaceae," T. M. Zennie and J. W. McClure, Aquatic Botany, 3, 49-54, 1977.
"Ascorbic Acid and Vitamin A Content of Wild Edible Plants in Ohio and Kentucky," T. M. Zennie and C. D. Ogzewalla, Economic Botany, 31, 76-79, January-March 1977.
Providing Information-Rich Solutions for Pharmaceutical Product Development Through the Use of Innovative Technologies II, 2007 Pittsburgh Conference and Exposition, Chicago, Illinois, February 26-March 1st.
"Providing Information-Rich Solutions for Pharmaceutical Product Development Through the Use of Innovative Technologies", CPSA 2006 (Chemical and Pharmaceutical Structure Analysis), Princeton, NJ, October 17-19, 2006.
Reaction NMR: A Method for Real Time Monitoring of Chemical Reactions and Processes. SMASH Conference (Small Molecules Are Still Hot), Burlington, Vt, September 10-13, 2006.
Application of At-Column-Dilution Sample Delivery System to Improve the Efficiency of LC-NMR Analyses" Poster Co-author, Lilly Expo 2005, April 12, 2005.
Identification of Multiple Impurities Responsible for the Discolored Duloxetine HCl. Poster Co-author, Lilly Expo 2005, April 12, 2005
"NMR Room Design, Installation and Setup Considerations" Experiment NMR Conference (ENC), Association of Managers of Magnetic Resonance Laboratories, Savannah, GA, March 31, 2003.
"Isolation, Identification and Structural Confirmation of the Polar and Non-polar Impurities in the Bulk Drug CI-1027", Pfizer Annual Analytical Symposium, Newport, Rhode Island, October 8-9, 2002.
"Screening and Optimization of an Asymmetric Reduction of diketoesters: Progress towards an Alternative Process for Atorvastatin" Co-author. 2002 Global CRD Science and Technology Forum, La Jolla, Ca, July 14-15, 2002.
"NMR in Pfizer Holland Chemical Development and the Isolation and Identification of Anticarcinogens from Food Using NMR and Mass Spectrometry", Invited Lecture, Purdue University, Sponsored by the Departments of Medicinal Chemistry, Food and Nutrition, and Biochemistry, for the opening of the new Botanical Center for the study of Nutraceuticals, West Lafayette, IN, February 19, 2001.
"The Use of NMR in the Chemical Development of Intermediates and Bulk Drugs", Pfizer/Hope College Distinguished Scholars Symposium, Symposium on Analytical Chemistry, October 6, 2000, Holland, Michigan
"An HPLC Method for PD0198961 and Identification of a Late Eluting Impurity Using NMR and APCI LC/MS." Parke-Davis Annual Analytical Symposium, Holland, MI, October 6-7, 1999.
"Identification of an Unknown Peak (1.4 rrt) in the Assay of Procainamide HCl." Parke-Davis Annual Analytical Symposium, Holland, MI, October 6-7, 1999.
"1H NMR of a Critical Intermediate of Atorvastatin to Monitor Stability and Degradation Products." Parke-Davis Annual Analytical Symposium, Morris Plains, NJ, October 7-8, 1998.
"HPLC Separation and LC/MS Identification of the Process Impurities Present in CI-1029 API and Corresponding Intermediates." Poster Presentation, Parke-Davis Annual Analytical Symposium, Morris Plains, NJ, October 7-8, 1998.
“How Do We Manage Open Access Technology?”, Parke Davis Annual Analytical Symposium, Ann Arbor, MI October 1-2 1997.
“History of Early Medicine”, Aquinas College, Aquinas College Annual Science Award Banquet, April 25, 1997.
“History of Plant Medicine”, Hope College, Hope Academy of Senior Professionals, Monthly Meeting, Janurary 24, 1997.
“Isolation and Identification of the Early Eluting Impurity: Bis Lactone (PD167129) in CI981 (Atorvastatin) Lactone.” Parke Davis Annual Analytical Symposium, Holland, MI, October 9-10, 1996.
"Isolation and Identification of the Major Process Impurity in CI981 Final CD-2271", Parke-Davis 1994 Annual Analytical Symposium, Ann Arbor, Michigan. October 14, 1994.
"Isolation and Identification of Scale-up and Degradation Impurities Using Hplc, NMR and Mass Specrometry. Parke-Davis 1993 Annual Analytical Symposium, Holland Michigan. October 26-27, 1993.
"Recent Developments in the Chemistry of Natural Products," West Michigan Local Section of the American Chemical Society, Hope College, Holland, Michigan. March 17, 1993.
"Isolation , Identification, Quantification and Production of the Z-isomer of CI979 HCl. Parke-Davis 1991 Annual Analytical Symposium, Ann Arbor, Michigan September 19-20, 1991.
"The Effect of the Plant Glucosinolate Glucolimnanthin on the Metabolism of Benzo(a)pyrene," Ohio Valley Association of Cancer Centers, Ohio State University, June 1986.
"Two New Pyrrole Alkaloids from Quararibea funebris Flowers," 27th Annual Meeting of the American Society of Pharmacognosy, University of Michigan, Ann Arbor, Michigan, July 1986.
"Funebrine, a Structurally Novel Pyrrole Alkaloid, and Other Gamma-Hydroxy- Isoleucine Related Metabolites of Quararibea funebris Llave Vischer (Bombacaceae)," 187th American Chemical Society National Meeting, St. Louis, Missouri, April 1984.
"Funebrine, a Structurally Novel Pyrrole Alkaloid from Quararibea funebris Bombacaceae," American Society of Pharmacognosy Annual Meeting, University of Mississippi, Oxford, Miss., July 1983.
"The Phytochemistry and Ethnopharmacology of a Mexican Medicinal Plant, Quararibea funebris, Bombacaceae," Society for Economic Botany Annual Meeting, Miami University, Oxford, Ohio, June 1983.
"Isolation of Two Novel Enamine and Enol Lactones from Quararibea funebris, Vischer (Bombacaceae)," American Society of Pharmacognosy Annual Meeting, University of Pittsburgh, Pittsburgh, Pennsylvania, August 1982.
"Phytochemistry of Quararibea funebris," New England Regional Meeting of Medicinal Chemists and Pharmacognosists Annual Meeting, University of Rhode Island, Providence, Rhode Island, April 1982.
"The Phytochemistry of Schefflera venulosa, New England Regional Meeting of Medicinal Chemists and Pharmacognosists, University of Connecticut, Stoors, Connecticut, 1980.
HONORARY SOCIETIES
Sigma Xi, Rho Chi, and Phi Kappa Phi.